Last update
3/23/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.6
USERS' SCORE
Good
Based on 10 Reviews
8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Sodium (from Sodium Hyaluronate)
10 mg
< 1 %
Hyaluronic Acid (from Sodium Hyaluronate)
100 mg
†
L-Proline (Free-Form)
100 mg
†
Alpha Lipoic Acid
50 mg
†
Grape Seed Extract (Vitis vinifera)(Standardized for Polyphenols)
25 mg
†
Top Medical Research Studies
3
No additional benefits from HA injections
We examined whether adding hyaluronic acid (HA) injections to physical therapy (PT) could improve outcomes for patients with frozen shoulder. In a well-structured study, 70 participants were divided into two groups—with one receiving HA injections alongside PT, while the other focused solely on PT.
After assessing their shoulder movement, pain, and quality of life, we found no significant extra benefits from the HA injections. This suggests that continuing with just PT could be a more cost-effective approach for managing this condition.
After assessing their shoulder movement, pain, and quality of life, we found no significant extra benefits from the HA injections. This suggests that continuing with just PT could be a more cost-effective approach for managing this condition.
Read More
8
We investigated how ultrasound-guided hyaluronic acid injections perform against steroid injections in treating frozen shoulder, specifically looking at pain relief and improved range of motion.
In a randomized trial with 100 participants, we treated groups either with a steroid injection or hyaluronic acid combined with capsular distension.
Both treatments proved effective, but we found that the hyaluronic acid approach particularly boosted passive external rotation more than steroids alone.
This suggests a promising option for managing this challenging condition.
In a randomized trial with 100 participants, we treated groups either with a steroid injection or hyaluronic acid combined with capsular distension.
Both treatments proved effective, but we found that the hyaluronic acid approach particularly boosted passive external rotation more than steroids alone.
This suggests a promising option for managing this challenging condition.
Read More
7
We conducted a systematic review and meta-analysis to investigate how effective hyaluronic acid (HA) injections are compared to corticosteroid (CS) injections for addressing frozen shoulder, or adhesive capsulitis.
We analyzed seven studies out of over ten thousand articles. Our findings indicate that while CS injections may provide quicker pain relief, HA injections show similar effectiveness after six to twelve weeks.
Therefore, HA could be a good option for patients needing multiple injections or looking for a treatment with fewer side effects.
We analyzed seven studies out of over ten thousand articles. Our findings indicate that while CS injections may provide quicker pain relief, HA injections show similar effectiveness after six to twelve weeks.
Therefore, HA could be a good option for patients needing multiple injections or looking for a treatment with fewer side effects.
Read More
Most Useful Reviews
9
No more problems
Awesome! I've worked in a physically demanding job and previously had issues with both shoulder and elbow joints. Since I started taking hyaluronic acid, all my problems have vanished. I highly recommend this product.
Read More
9
Pain disappeared
Excellent! I began taking this product while experiencing shoulder pain. After a month, I noticed the pain at night vanished, and eventually, it completely disappeared.
Read More
9
Shoulder improvement
Hyaluronic acid has truly aided my shoulder!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.6
- All Researches
9
We explored the effectiveness of intra-articular injections combining hyaluronic acid and tramadol in treating adhesive capsulitis, commonly known as frozen shoulder.
We compared this approach to hyaluronic acid injections alone among thirty patients. The results showed that patients receiving both treatments experienced faster pain relief without adverse effects.
However, the study also suggests that while the combination therapy is beneficial, it does not indicate a significant overall improvement over hyaluronic acid alone.
We compared this approach to hyaluronic acid injections alone among thirty patients. The results showed that patients receiving both treatments experienced faster pain relief without adverse effects.
However, the study also suggests that while the combination therapy is beneficial, it does not indicate a significant overall improvement over hyaluronic acid alone.
Read More
8
We explored the effectiveness of a new injectable hydrogel combining hyaluronic acid and pluronic F-127 to treat frozen shoulder, a condition that causes joint stiffness due to inflammation.
Our study revealed that this hydrogel, loaded with dexamethasone and collagenase, significantly improved joint mobility compared to traditional medication alone. The hydrogel was designed to release its drugs steadily for about 10 days, which helps break down excessive collagen that limits movement.
Overall, our findings highlight the potential of this combined hydrogel therapy as a promising option for individuals dealing with frozen shoulder.
Our study revealed that this hydrogel, loaded with dexamethasone and collagenase, significantly improved joint mobility compared to traditional medication alone. The hydrogel was designed to release its drugs steadily for about 10 days, which helps break down excessive collagen that limits movement.
Overall, our findings highlight the potential of this combined hydrogel therapy as a promising option for individuals dealing with frozen shoulder.
Read More
8
Hyaluronic acid enhances treatment outcomes
We assessed the impact of combining ultrasound-guided hydrodilatation with hyaluronic acid and physical therapy versus physical therapy alone on patients with frozen shoulder.
In a well-structured study involving 62 participants, half received the combined treatment while the other half followed just physical therapy.
Results showed that the group receiving the hyaluronic acid along with physical therapy experienced additional benefits, suggesting this combination could enhance recovery up to 12 weeks post-treatment.
In a well-structured study involving 62 participants, half received the combined treatment while the other half followed just physical therapy.
Results showed that the group receiving the hyaluronic acid along with physical therapy experienced additional benefits, suggesting this combination could enhance recovery up to 12 weeks post-treatment.
Read More
8
We investigated how ultrasound-guided hyaluronic acid injections perform against steroid injections in treating frozen shoulder, specifically looking at pain relief and improved range of motion.
In a randomized trial with 100 participants, we treated groups either with a steroid injection or hyaluronic acid combined with capsular distension.
Both treatments proved effective, but we found that the hyaluronic acid approach particularly boosted passive external rotation more than steroids alone.
This suggests a promising option for managing this challenging condition.
In a randomized trial with 100 participants, we treated groups either with a steroid injection or hyaluronic acid combined with capsular distension.
Both treatments proved effective, but we found that the hyaluronic acid approach particularly boosted passive external rotation more than steroids alone.
This suggests a promising option for managing this challenging condition.
Read More
8
We assessed the effectiveness of hyaluronic acid treatment for frozen shoulder in a study involving 87 patients. Each participant had severe pain and limited movement, with some receiving hyaluronic acid injections prior to surgery.
After arthroscopic capsular release, we observed that improvements in shoulder function correlated with the severity of tendon adhesions. While all patients exhibited enhanced movement and strength post-surgery, hyaluronic acid's specific benefit remains unclear. Ultimately, it appears while some treatments help, hyaluronic acid may not have played a significant role.
After arthroscopic capsular release, we observed that improvements in shoulder function correlated with the severity of tendon adhesions. While all patients exhibited enhanced movement and strength post-surgery, hyaluronic acid's specific benefit remains unclear. Ultimately, it appears while some treatments help, hyaluronic acid may not have played a significant role.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
No more problems
Awesome! I've worked in a physically demanding job and previously had issues with both shoulder and elbow joints. Since I started taking hyaluronic acid, all my problems have vanished. I highly recommend this product.
Read More
9
Pain disappeared
Excellent! I began taking this product while experiencing shoulder pain. After a month, I noticed the pain at night vanished, and eventually, it completely disappeared.
Read More
9
Shoulder improvement
Hyaluronic acid has truly aided my shoulder!
Read More
7.5
Less pain
As an older woman, I observed less shoulder pain and smoother, less crepe-like skin after only two weeks of using this product. Additionally, I appreciate the double strength capsules as I only need to take one.
Read More
7.5
Frozen shoulder aid
It truly helped with my frozen shoulder and knee pain.
Read More
Frequently Asked Questions
2
No improvement noted
I believe supplements take longer to show effects. Unfortunately, I haven’t experienced any improvement for my frozen shoulder.
9
Pain disappeared
Excellent! I began taking this product while experiencing shoulder pain. After a month, I noticed the pain at night vanished, and eventually, it completely disappeared.
7.5
Joint improvement
I repurchased this to enhance my shoulder joint function. After three months alongside vitamin C, I noticed not only improvements in my shoulder but also my facial skin became more hydrated and youthful, with better colour. My nails and hair improved too.
7
We conducted a systematic review and meta-analysis to investigate how effective hyaluronic acid (HA) injections are compared to corticosteroid (CS) injections for addressing frozen shoulder, or adhesive capsulitis.
We analyzed seven studies out of over ten thousand articles. Our findings indicate that while CS injections may provide quicker pain relief, HA injections show similar effectiveness after six to twelve weeks.
Therefore, HA could be a good option for patients needing multiple injections or looking for a treatment with fewer side effects.
We analyzed seven studies out of over ten thousand articles. Our findings indicate that while CS injections may provide quicker pain relief, HA injections show similar effectiveness after six to twelve weeks.
Therefore, HA could be a good option for patients needing multiple injections or looking for a treatment with fewer side effects.
5
We wanted to find out how effective hyaluronic acid injections are for patients with frozen shoulder compared to corticosteroids. In a study with 68 participants, patients received either treatment and were evaluated after 2 and 12 weeks.
Results showed that while both treatments helped improve shoulder function and pain, there were no significant differences between the two groups. Specifically, internal rotation was initially less in the hyaluronic group but improved over time. Ultimately, both options can offer benefits for individuals suffering from this condition.
Results showed that while both treatments helped improve shoulder function and pain, there were no significant differences between the two groups. Specifically, internal rotation was initially less in the hyaluronic group but improved over time. Ultimately, both options can offer benefits for individuals suffering from this condition.
8
Hyaluronic acid enhances treatment outcomes
We assessed the impact of combining ultrasound-guided hydrodilatation with hyaluronic acid and physical therapy versus physical therapy alone on patients with frozen shoulder.
In a well-structured study involving 62 participants, half received the combined treatment while the other half followed just physical therapy.
Results showed that the group receiving the hyaluronic acid along with physical therapy experienced additional benefits, suggesting this combination could enhance recovery up to 12 weeks post-treatment.
In a well-structured study involving 62 participants, half received the combined treatment while the other half followed just physical therapy.
Results showed that the group receiving the hyaluronic acid along with physical therapy experienced additional benefits, suggesting this combination could enhance recovery up to 12 weeks post-treatment.
8
We aimed to assess how well a combination treatment of hyaluronic acid and a corticosteroid helps people with frozen shoulder. In our study of 30 participants, we found that those receiving the combined injections showed notable improvements in pain and shoulder movement after six months.
The hyaluronic acid treatment seems to enhance outcomes, likely due to its effects on joint tissue and fluid management. While both treatment groups experienced benefits, the combination therapy proved to be particularly effective for healing adhesive capsulitis.
The hyaluronic acid treatment seems to enhance outcomes, likely due to its effects on joint tissue and fluid management. While both treatment groups experienced benefits, the combination therapy proved to be particularly effective for healing adhesive capsulitis.
3
No additional benefits from HA injections
We examined whether adding hyaluronic acid (HA) injections to physical therapy (PT) could improve outcomes for patients with frozen shoulder. In a well-structured study, 70 participants were divided into two groups—with one receiving HA injections alongside PT, while the other focused solely on PT.
After assessing their shoulder movement, pain, and quality of life, we found no significant extra benefits from the HA injections. This suggests that continuing with just PT could be a more cost-effective approach for managing this condition.
After assessing their shoulder movement, pain, and quality of life, we found no significant extra benefits from the HA injections. This suggests that continuing with just PT could be a more cost-effective approach for managing this condition.
References
- Wang Z, Shen M, Wu S. Efficacy comparison of sodium hyaluronate, corticosteroids, and autologous platelet-rich plasma in the treatment of primary frozen shoulder. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2024;49:1271. 10.11817/j.issn.1672-7347.2024.240219
- Uhm KE, Chang MC. Comparison of Effectiveness of Intraarticular Hyaluronate and Corticosteroid injections in Adhesive Capsulitis: A Systematic Review and Meta-analysis. Pain Physician. 2024;27:387. PubMed
- Zhang J, Song Y, Zhu L, You Y, Hu J, et al. An injectable thermosensitive hyaluronic acid/pluronic F-127 hydrogel for deep penetration and combination therapy of frozen shoulder. Int J Biol Macromol. 2024;263:130342. 10.1016/j.ijbiomac.2024.130342
- Wu SY, Hsu PC, Tsai YY, Huang JR, Wang KA, et al. Efficacy of combined ultrasound-guided hydrodilatation with hyaluronic acid and physical therapy in patients with adhesive capsulitis: A randomised controlled trial. Clin Rehabil. 2024;38:202. 10.1177/02692155231200089
- Ahn Y, Moon YS, Park GY, Cho SC, Lee YJ, et al. Efficacy of Intra-articular Triamcinolone and Hyaluronic Acid in a Frozen Shoulder Rat Model. Am J Sports Med. 2023;51:2881. 10.1177/03635465231188524
- Mao B, Peng R, Zhang Z, Zhang K, Li J, et al. The Effect of Intra-articular Injection of Hyaluronic Acid in Frozen Shoulder: a Systematic Review and Meta-analysis of Randomized Controlled Trials. J Orthop Surg Res. 2022;17:128. 10.1186/s13018-022-03017-4
- Akhtar M, Nadeem RDA, Shah Gillani SF, Cheema OI, Nadeem MR. Comparison of intra articular NSAID (ketorolac) injection versus hyaluronic acid injection for the mean decrease of pain score (according to UCLA shoulder rating scale) in the management of adhesive capsulitis. Pak J Pharm Sci. 2019;32:953. PubMed
- Papalia R, Tecame A, Vadalà G, Russo F, Perna M, et al. The use of hyaluronic acid in the treatment of shoulder capsulitis: a systematic review. J Biol Regul Homeost Agents. 2017;31:23. PubMed
- Kim KH, Suh JW, Oh KY. The effect of intra-articular hyaluronate and tramadol injection on patients with adhesive capsulitis of the shoulder. J Back Musculoskelet Rehabil. 2017;30:913. 10.3233/BMR-160641
- Lim TK, Koh KH, Shon MS, Lee SW, Park YE, et al. Intra-articular injection of hyaluronate versus corticosteroid in adhesive capsulitis. Orthopedics. 2014;37:e860. 10.3928/01477447-20140924-51
- Park KD, Nam HS, Lee JK, Kim YJ, Park Y. Treatment effects of ultrasound-guided capsular distension with hyaluronic acid in adhesive capsulitis of the shoulder. Arch Phys Med Rehabil. 2013;94:264. 10.1016/j.apmr.2012.10.002
- Hsieh LF, Hsu WC, Lin YJ, Chang HL, Chen CC, et al. Addition of intra-articular hyaluronate injection to physical therapy program produces no extra benefits in patients with adhesive capsulitis of the shoulder: a randomized controlled trial. Arch Phys Med Rehabil. 2012;93:957. 10.1016/j.apmr.2012.01.021
- Kanbe K, Inoue K, Inoue Y. Dynamic movement of the long head of the biceps tendon in frozen shoulders. J Orthop Surg (Hong Kong). 2008;16:295. PubMed
- Calis M, Demir H, Ulker S, Kirnap M, Duygulu F, et al. Is intraarticular sodium hyaluronate injection an alternative treatment in patients with adhesive capsulitis?. Rheumatol Int. 2006;26:536. PubMed
- Tamai K, Mashitori H, Ohno W, Hamada J, Sakai H, et al. Synovial response to intraarticular injections of hyaluronate in frozen shoulder: a quantitative assessment with dynamic magnetic resonance imaging. J Orthop Sci. 2004;9:230. PubMed
- Rovetta G, Monteforte P. Intraarticular injection of sodium hyaluronate plus steroid versus steroid in adhesive capsulitis of the shoulder. Int J Tissue React. 1998;20:125. PubMed
Data last updated:
